Stadium: Rice-Totten Stadium Round: 1
Home Manager: Vincent Dancy Away Manager: Clarence McKinney
| NCAAF | 2018/10/27 19:00 | Texas Southern Tigers v Mississippi Valley State | W | 42-14 |
| NCAAF | 2017/11/04 18:00 | Mississippi Valley State v Texas Southern Tigers | W | 21-38 |
| NCAAF | 2019/10/19 19:00 | Southern v Texas Southern Tigers | L | 28-21 |
| NCAAF | 2019/10/12 19:00 | Texas Southern Tigers v Missouri S&t Miners | L | 20-23 |
| NCAAF | 2019/10/05 19:00 | Texas Southern Tigers v Alabama | L | 28-35 |
| NCAAF | 2019/09/28 23:00 | Texas Southern Tigers v Houston Christian | L | 31-68 |
| NCAAF | 2019/09/14 23:30 | Texas Southern Tigers v Lafayette | L | 6-77 |
| NCAAF | 2019/09/07 23:00 | Texas Southern Tigers v Incarnate Word | L | 44-63 |
| NCAAF | 2019/08/31 22:30 | Prairie View v Texas Southern Tigers | L | 44-23 |
| NCAAF FCS | 2018/11/24 19:00 | Texas Southern Tigers v Prairie View | L | 14-60 |
| NCAAF | 2019/10/19 19:00 | Jackson State v Mississippi Valley State | L | 31-28 |
| NCAAF | 2019/10/12 18:00 | Mississippi Valley State v Arkansas Pine Bluff | L | 6-38 |
| NCAAF | 2019/10/05 20:00 | Mississippi Valley State v Lynchburg Dragons | W | 31-23 |
| NCAAF | 2019/09/28 23:00 | Mississippi Valley State v Alcorn State | L | 19-45 |
| NCAAF | 2019/09/21 23:00 | Bethune Cookman v Mississippi Valley State | L | 22-6 |
| NCAAF | 2019/09/07 23:00 | Mississippi Valley State v Lamar | L | 20-23 |
| NCAAF | 2019/08/31 23:00 | Mississippi Valley State v Tennessee State | L | 20-26 |
| NCAAF FCS | 2018/11/22 20:00 | Mississippi Valley State v Alabama State | L | 24-31 |