Home History
| NCAAF | 2000/10/21 12:00 | Maryland v Wake Forest | L | 37-7 |
| NCAAF | 2000/10/14 12:00 | Georgia Tech v Wake Forest | L | 52-20 |
| NCAAF | 2000/10/07 12:00 | Wake Forest v Vanderbilt | L | 10-17 |
| NCAAF | 2000/09/30 12:00 | Wake Forest v Virginia | L | 10-27 |
| NCAAF | 2000/09/16 12:00 | Clemson v Wake Forest | L | 55-7 |
| NCAAF | 2000/09/09 12:00 | Wake Forest v North Carolina | L | 14-35 |
| NCAAF | 2000/08/31 12:00 | Wake Forest v Appalachian St | L | 16-20 |
Away History
| NCAAF | 2000/10/28 12:00 | Duke v Maryland | L | 9-20 |
| NCAAF | 2000/10/21 12:00 | Georgia Tech v Duke | L | 45-10 |
| NCAAF | 2000/10/14 12:00 | Florida State v Duke | L | 63-14 |
| NCAAF | 2000/09/30 12:00 | Duke v Clemson | L | 22-52 |
| NCAAF | 2000/09/23 12:00 | Vanderbilt v Duke | L | 26-7 |
| NCAAF | 2000/09/16 12:00 | Duke v Virginia | L | 10-26 |
| NCAAF | 2000/09/09 12:00 | Northwestern v Duke | L | 38-5 |
| NCAAF | 2000/09/02 12:00 | Duke v East Carolina | L | 0-38 |