Head to Head
| MLB Exhibition | 2021/03/20 20:05 | CLE Guardians v CHI White Sox | L | 2-6 |
| MLB - Spring Training | 2021/03/06 20:05 | CHI White Sox v CLE Guardians | L | 7-0 |
| MLB | 2020/09/24 22:10 | CHI White Sox v CLE Guardians | W | 4-5 |
| MLB | 2020/09/23 22:10 | CHI White Sox v CLE Guardians | W | 2-3 |
| MLB | 2020/09/22 22:10 | CHI White Sox v CLE Guardians | W | 3-5 |
| MLB | 2020/09/21 22:10 | CHI White Sox v CLE Guardians | W | 4-7 |
| MLB | 2020/08/09 23:08 | CLE Guardians v CHI White Sox | W | 5-4 |
| MLB | 2020/08/08 18:10 | CLE Guardians v CHI White Sox | W | 7-1 |
Home History
| MLB | 2021/04/11 17:10 | DET Tigers v CLE Guardians | W | 2-5 |
| MLB | 2021/04/10 22:10 | DET Tigers v CLE Guardians | W | 3-11 |
| MLB | 2021/04/09 23:10 | DET Tigers v CLE Guardians | W | 1-4 |
| MLB | 2021/04/07 17:10 | KC Royals v CLE Guardians | W | 2-4 |
| MLB | 2021/04/05 20:10 | KC Royals v CLE Guardians | L | 3-0 |
| MLB | 2021/04/04 17:10 | CLE Guardians v DET Tigers | W | 9-3 |
| MLB | 2021/04/03 17:10 | CLE Guardians v DET Tigers | L | 2-5 |
| MLB | 2021/04/01 17:10 | CLE Guardians v DET Tigers | L | 2-3 |
Away History
| MLB | 2021/04/11 18:10 | KC Royals v CHI White Sox | L | 4-3 |
| MLB | 2021/04/08 22:20 | KC Royals v CHI White Sox | W | 0-6 |
| MLB | 2021/04/07 20:10 | CHI White Sox v SEA Mariners | L | 4-8 |
| MLB | 2021/04/07 02:10 | CHI White Sox v SEA Mariners | W | 10-4 |
| MLB | 2021/04/06 02:10 | CHI White Sox v SEA Mariners | W | 6-0 |
| MLB | 2021/04/05 00:37 | CHI White Sox v LA Angels | L | 4-7 |
| MLB | 2021/04/04 01:07 | CHI White Sox v LA Angels | L | 3-5 |
| MLB | 2021/04/03 01:38 | CHI White Sox v LA Angels | W | 12-8 |