[8] Leyton Orient 4-1 Swindon [4] 2021-12-07 19:45
Stadium: Matchroom Stadium Round: 20
Referee: Darren Drysdale Home Manager: Kenneth Francis Jackett Away Manager: Ben Garner
Head to Head
| Anglia - League 2 | 2019/09/07 14:00 | Leyton Orient v Swindon | L | 1-3 |
| Anglia - League 1 | 2015/05/03 11:15 | Swindon v Leyton Orient | D | 2-2 |
| Anglia - League 1 | 2014/10/04 14:00 | Leyton Orient v Swindon | L | 1-2 |
Home History
| Anglia - FA Cup | 2021/12/04 15:00 | Leyton Orient v Tranmere | W | 4-0 |
| Anglia - EFL Trophy | 2021/11/30 19:00 | Leyton Orient v Milton Keynes Dons | L | 4-5 |
| Anglia - League 2 | 2021/11/27 15:00 | Northampton v Leyton Orient | L | 1-0 |
| Anglia - League 2 | 2021/11/23 19:45 | Scunthorpe v Leyton Orient | D | 1-1 |
| Anglia - League 2 | 2021/11/20 15:00 | Leyton Orient v Sutton Utd | W | 4-1 |
| Anglia - League 2 | 2021/11/13 15:00 | Rochdale v Leyton Orient | D | 2-2 |
| Anglia - EFL Trophy | 2021/11/09 19:00 | Leyton Orient v Charlton | W | 1-0 |
| Anglia - FA Cup | 2021/11/06 15:00 | Leyton Orient v Ebbsfleet United | W | 1-0 |
Away History
| Anglia - FA Cup | 2021/12/04 15:00 | Walsall v Swindon | W | 1-2 |
| Anglia - EFL Trophy | 2021/11/30 19:45 | Swindon v Colchester | L | 1-2 |
| Anglia - League 2 | 2021/11/27 15:00 | Swindon v Harrogate Town | D | 1-1 |
| Anglia - League 2 | 2021/11/23 19:45 | Swindon v Hartlepool | W | 3-1 |
| Anglia - League 2 | 2021/11/20 15:00 | Newport County v Swindon | W | 1-2 |
| Anglia - EFL Trophy | 2021/11/09 19:00 | Swindon v Newport County | W | 1-0 |
| Anglia - FA Cup | 2021/11/06 15:00 | Crewe v Swindon | W | 0-3 |
| Anglia - League 2 | 2021/10/30 14:00 | Oldham v Swindon | W | 1-3 |