Stadium: Rice-Totten Stadium Round: 1
Home Manager: Vincent Dancy Away Manager: Deion Sanders
| NCAAF | 2021/03/14 19:00 | Mississippi Valley State v Jackson State | W | 7-43 |
| NCAAF | 2019/10/19 19:00 | Jackson State v Mississippi Valley State | W | 31-28 |
| NCAAF | 2018/10/13 19:00 | Mississippi Valley State v Jackson State | W | 7-23 |
| NCAAF | 2017/10/28 19:00 | Mississippi Valley State v Jackson State | W | 5-24 |
| NCAAF | 2021/10/23 18:00 | Bethune Cookman v Jackson State | W | 12-42 |
| NCAAF | 2021/10/16 19:00 | Alabama State v Jackson State | W | 7-28 |
| NCAAF | 2021/10/09 19:00 | Jackson State v Alabama | W | 61-15 |
| NCAAF | 2021/09/25 19:00 | Jackson State v Delta State | W | 24-17 |
| NCAAF | 2021/09/19 00:00 | Jackson State v UL Monroe | L | 7-12 |
| NCAAF | 2021/09/11 23:00 | Jackson State v Tennessee State | W | 38-16 |
| NCAAF | 2021/09/05 19:00 | Jackson State v Florida A&M | W | 7-6 |
| NCAAF | 2021/04/10 19:00 | Alabama v Jackson State | L | 52-43 |
| NCAAF | 2021/10/23 20:00 | Florida A&M v Mississippi Valley State | L | 31-28 |
| NCAAF | 2021/10/16 20:00 | Alcorn State v Mississippi Valley State | L | 24-12 |
| NCAAF | 2021/10/09 20:00 | Mississippi Valley State v Bethune Cookman | W | 20-14 |
| NCAAF | 2021/10/02 20:00 | North Carolina Central v Mississippi Valley State | W | 16-17 |
| NCAAF | 2021/09/26 19:00 | Southern v Mississippi Valley State | L | 38-25 |
| NCAAF | 2021/09/18 23:00 | Mississippi Valley State v Stephen F. Austin | L | 13-58 |
| NCAAF | 2021/09/03 00:00 | Mississippi Valley State v Murray State | L | 0-35 |
| NCAAF | 2021/04/10 19:00 | Mississippi Valley State v Alabama State | L | 17-42 |