Stadium: Memorial Stadium (TX) Round: 1
Home Manager: Todd Whitten Away Manager: Nathan Brown
| NCAAF | 2021/11/13 22:00 | Stephen F. Austin v Central Arkansas | L | 27-14 |
| NCAAF | 2021/11/06 21:00 | Central Arkansas v Texas Wesleyan Rams | W | 63-3 |
| NCAAF | 2021/10/30 18:00 | Central Arkansas v Jacksonville State | W | 38-14 |
| NCAAF | 2021/10/23 23:00 | Central Arkansas v Lamar | W | 49-38 |
| NCAAF | 2021/10/16 21:00 | Eastern Kentucky v Central Arkansas | L | 38-35 |
| NCAAF | 2021/10/02 23:00 | Central Arkansas v Abilene Christian | W | 42-21 |
| NCAAF | 2021/09/25 21:00 | Sam Houston State v Central Arkansas | L | 45-35 |
| NCAAF | 2021/09/18 23:00 | Arkansas Pine Bluff v Central Arkansas | W | 23-45 |
| NCAAF | 2021/11/13 19:00 | Tarleton State v Abilene Christian | L | 3-29 |
| NCAAF | 2021/11/06 23:00 | Lamar v Tarleton State | W | 21-42 |
| NCAAF | 2021/10/30 23:00 | Sam Houston State v Tarleton State | L | 45-27 |
| NCAAF | 2021/10/23 23:00 | Tarleton State v Midwestern State University Mustangs | W | 17-14 |
| NCAAF | 2021/10/17 01:00 | Tarleton State v Utah Tech | W | 41-20 |
| NCAAF | 2021/10/02 19:00 | Tarleton State v Eastern Kentucky | L | 3-20 |
| NCAAF | 2021/09/25 23:00 | Tarleton State v N. Mexico H. Cowboys | W | 40-21 |
| NCAAF | 2021/09/18 23:00 | Southern Utah v Tarleton State | L | 40-35 |