[13] Leyton Orient 2-4 Northampton [4] 2022-04-23 14:00
Stadium: Matchroom Stadium Round: 44
Referee: Darren Handley Home Manager: Richie Wellens Away Manager: Jon Brady
Head to Head
| Anglia - League 2 | 2021/11/27 15:00 | Northampton v Leyton Orient | L | 1-0 |
| Europa - Amicale | 2020/08/22 12:00 | Northampton v Leyton Orient | L | 1-0 |
| Anglia - League 2 | 2020/01/21 19:45 | Leyton Orient v Northampton | D | 1-1 |
| Anglia - League 2 | 2019/10/05 14:00 | Northampton v Leyton Orient | W | 0-1 |
| Anglia - League 2 | 2016/02/13 15:00 | Leyton Orient v Northampton | L | 0-4 |
| Anglia - League 2 | 2015/09/26 14:00 | Northampton v Leyton Orient | D | 1-1 |
| Anglia - EFL Trophy | 2014/11/11 19:45 | Leyton Orient v Northampton | W | 2-0 |
| Europa - Amicale | 2014/07/26 14:00 | Northampton v Leyton Orient | W | 0-1 |
Home History
| Anglia - League 2 | 2022/04/18 14:00 | Swindon v Leyton Orient | W | 1-2 |
| Anglia - League 2 | 2022/04/15 14:00 | Leyton Orient v Scunthorpe | W | 3-0 |
| Anglia - League 2 | 2022/04/09 14:00 | Sutton Utd v Leyton Orient | L | 1-0 |
| Anglia - League 2 | 2022/04/02 14:00 | Walsall v Leyton Orient | W | 0-2 |
| Anglia - League 2 | 2022/03/29 18:45 | Oldham v Leyton Orient | L | 2-0 |
| Anglia - League 2 | 2022/03/26 15:00 | Leyton Orient v Barrow | W | 2-0 |
| Anglia - League 2 | 2022/03/22 19:00 | Harrogate Town v Leyton Orient | W | 0-3 |
| Anglia - League 2 | 2022/03/19 15:00 | Leyton Orient v Rochdale | W | 3-1 |
Away History
| Anglia - League 2 | 2022/04/18 14:00 | Northampton v Harrogate Town | W | 3-0 |
| Anglia - League 2 | 2022/04/15 14:00 | Oldham v Northampton | W | 0-2 |
| Anglia - League 2 | 2022/04/09 14:00 | Northampton v Bradford | D | 0-0 |
| Anglia - League 2 | 2022/04/02 14:00 | Mansfield v Northampton | L | 1-0 |
| Anglia - League 2 | 2022/03/26 15:00 | Northampton v Hartlepool | W | 2-0 |
| Anglia - League 2 | 2022/03/19 15:00 | Northampton v Bristol Rovers | L | 0-1 |
| Anglia - League 2 | 2022/03/15 19:45 | Stevenage v Northampton | W | 1-2 |
| Anglia - League 2 | 2022/03/12 15:00 | Carlisle v Northampton | L | 2-1 |