Head to Head
| Chile - Primera Division | 2021/10/20 17:00 | La Serena v Colo Colo | L | 1-4 |
| Chile - Cupa | 2021/07/05 00:00 | Colo Colo v La Serena | L | 4-0 |
| Chile - Cupa | 2021/07/01 19:30 | La Serena v Colo Colo | L | 1-3 |
| Chile - Primera Division | 2021/06/06 22:00 | Colo Colo v La Serena | L | 2-0 |
| Chile - Primera Division | 2020/12/08 21:30 | Colo Colo v La Serena | W | 0-2 |
| Chile - Primera Division | 2020/03/07 15:00 | La Serena v Colo Colo | L | 1-2 |
| Chile - Cupa | 2017/08/03 00:00 | Colo Colo v La Serena | L | 4-0 |
| Chile - Cupa | 2017/07/09 19:30 | La Serena v Colo Colo | W | 4-1 |
Home History
| Chile - Primera Division | 2022/02/04 23:00 | O'Higgins v La Serena | L | 3-0 |
| Chile - Primera Division | 2021/12/04 21:00 | La Serena v Santiago Wanderers | D | 0-0 |
| Chile - Primera Division | 2021/11/28 21:00 | Union La Calera v La Serena | W | 1-2 |
| Chile - Primera Division | 2021/11/13 18:30 | La Serena v Universidad Catolica | L | 0-2 |
| Chile - Primera Division | 2021/11/08 21:00 | CD Antofagasta v La Serena | D | 0-0 |
| Chile - Primera Division | 2021/10/29 20:50 | La Serena v Huachipato | D | 2-2 |
| Chile - Primera Division | 2021/10/25 19:00 | Palestino v La Serena | D | 3-3 |
| Chile - Primera Division | 2021/10/20 17:00 | La Serena v Colo Colo | L | 1-4 |
Away History
| Chile - Primera Division | 2022/02/06 23:30 | Colo Colo v Everton de Vina | W | 2-0 |
| Chile - Supercupa | 2022/01/23 22:00 | Universidad Catolica v Colo Colo | W | 0-2 |
| Europa - Amicale | 2022/01/18 00:00 | Boca Juniors v Colo Colo | L | 2-0 |
| Europa - Amicale | 2022/01/15 00:00 | Colo Colo v Universidad de Chile | W | 2-1 |
| Chile - Primera Division | 2021/12/04 21:00 | CD Antofagasta v Colo Colo | L | 1-0 |
| Chile - Primera Division | 2021/11/28 21:00 | Colo Colo v Union Espanola | L | 0-1 |
| Chile - Primera Division | 2021/11/14 21:30 | Curico Unido v Colo Colo | D | 0-0 |
| Chile - Primera Division | 2021/11/10 22:00 | Colo Colo v Melipilla | W | 1-0 |