[27] John Isner 4-6,6-3,6-4 Cristian Garin [29] 2022-04-09 19:30
Stadium: Stadium Court Round: 28 Ground: Clay
Head to Head
| ATP - Toronto | 2021/08/11 15:00 | John Isner v Cristian Garin | 4-6,6-3,6-4 |
| ATP - Paris | 2019/10/30 12:15 | Cristian Garin v John Isner | 7-6,7-6 |
| ATP - Montreal | 2019/08/07 21:15 | Cristian Garin v John Isner | 6-3,6-4 |
Home History
| ATP - Houston | 2022/04/08 23:00 | Frances Tiafoe v John Isner | 4-6,6-2,3-6 |
| ATP - Houston | 2022/04/08 01:55 | Steve Johnson v John Isner | 7-6,6-7,3-6 |
| ATP - Miami | 2022/03/25 18:05 | John Isner v Hugo Gaston | 6-7,4-6 |
| ATP - Indian Wells | 2022/03/16 21:30 | John Isner v Grigor Dimitrov | 3-6,6-7 |
| ATP - Indian Wells | 2022/03/15 22:05 | Diego Schwartzman v John Isner | 5-7,3-6 |
| ATP - Indian Wells | 2022/03/13 18:00 | Sam Querrey v John Isner | 6-7,6-7 |
| ATP - Acapulco | 2022/02/24 00:00 | Cameron Norrie v John Isner | 6-7,6-3,6-4 |
| ATP - Acapulco | 2022/02/22 00:00 | Fernando Verdasco v John Isner | 5-7,7-6,6-7 |
Away History
| ATP - Houston | 2022/04/08 20:00 | Cristian Garin v Taylor Fritz | 6-2,6-7,6-3 |
| ATP - Houston | 2022/04/07 19:00 | Cristian Garin v Jordan Thompson | 3-6,6-3,6-3 |
| ATP - Houston | 2022/04/05 23:20 | Cristian Garin v Jack Sock | 4-6,6-3,7-5 |
| ATP - Miami | 2022/03/26 16:25 | Pedro Martinez v Cristian Garin | 7-6,6-2 |
| ATP - Santiago | 2022/02/25 00:00 | Cristian Garin v Alejandro Tabilo | 3-6,3-6 |
| ATP - Rio de Janeiro | 2022/02/15 19:30 | Federico Coria v Cristian Garin | 6-2,6-0 |
| ATP - Cordoba | 2022/02/03 22:10 | Cristian Garin v Sebastian Baez | 6-4,1-6,1-6 |
| Australian Open | 2022/01/21 03:15 | Gael Monfils v Cristian Garin | 7-6,6-1,6-3 |