[10] Florida State 35-31 Louisville [13] 2022-09-16 23:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Mike Norvell
Head to Head
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | L | 31-23 |
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | L | 16-48 |
| NCAAF | 2019/09/21 19:30 | Louisville v Florida State | W | 24-35 |
| NCAAF | 2018/09/29 19:30 | Florida State v Louisville | W | 28-24 |
| NCAAF | 2017/10/21 16:00 | Florida State v Louisville | L | 28-31 |
| NCAAF | 2017/10/21 16:00 | Louisville v Florida State | L | 31-28 |
| NCAAF | 2016/09/17 16:00 | Florida State v Louisville | L | 20-63 |
| NCAAF | 2015/10/17 16:00 | Florida State v Louisville | W | 41-21 |
Home History
| NCAAF | 2022/09/04 23:30 | Florida State v LSU | W | 24-23 |
| NCAAF | 2022/08/27 22:30 | Duquesne v Florida State | W | 7-47 |
| NCAAF | 2021/11/27 17:00 | Florida State v Florida | L | 21-24 |
| NCAAF | 2021/11/20 17:00 | Florida State v Boston College | W | 26-23 |
| NCAAF | 2021/11/13 20:30 | Miami Florida v Florida State | W | 28-31 |
| NCAAF | 2021/11/06 20:00 | NC State v Florida State | L | 28-14 |
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | L | 20-30 |
| NCAAF | 2021/10/23 16:00 | Massachusetts v Florida State | W | 3-59 |
Away History
| NCAAF | 2022/09/09 23:30 | Louisville v Central Florida | W | 20-14 |
| NCAAF | 2022/09/04 00:00 | Louisville v Syracuse | L | 7-31 |
| NCAAF Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |