[15] Colchester 1-3 Leyton Orient [2] 2022-08-20 14:00
Stadium: JobServe Community Stadium Round: 5
Referee: Thomas Kirk Home Manager: Wayne Brown Away Manager: Richie Wellens
Head to Head
| Anglia - League 2 | 2022/03/01 19:45 | Colchester v Leyton Orient | D | 2-2 |
| Anglia - League 2 | 2022/02/05 15:00 | Leyton Orient v Colchester | W | 0-1 |
| Anglia - League 2 | 2021/02/06 15:00 | Leyton Orient v Colchester | D | 0-0 |
| Anglia - League 2 | 2020/11/14 15:00 | Colchester v Leyton Orient | W | 2-1 |
| Anglia - League 2 | 2019/12/26 13:00 | Leyton Orient v Colchester | W | 1-3 |
| Anglia - League 2 | 2019/09/21 14:00 | Colchester v Leyton Orient | W | 2-1 |
| Anglia - League 2 | 2017/04/29 14:00 | Leyton Orient v Colchester | W | 1-3 |
| Anglia - League 2 | 2016/11/12 15:00 | Colchester v Leyton Orient | L | 0-3 |
Home History
| Anglia - League 2 | 2022/08/16 18:45 | Colchester v Bradford | W | 1-0 |
| Anglia - League 2 | 2022/08/13 14:00 | Stockport v Colchester | L | 1-0 |
| Anglia - Cupa EFL | 2022/08/09 18:45 | Ipswich v Colchester | W | 0-1 |
| Anglia - League 2 | 2022/08/06 14:00 | Colchester v Carlisle | D | 1-1 |
| Anglia - League 2 | 2022/07/30 14:00 | Northampton v Colchester | L | 3-2 |
| Europa - Amicale | 2022/07/23 14:00 | Ebbsfleet United v Colchester | D | 2-2 |
| Europa - Amicale | 2022/07/19 18:30 | Colchester v Southend | D | 2-2 |
| Europa - Amicale | 2022/07/15 18:30 | Colchester v Millwall | L | 0-1 |
Away History
| Anglia - League 2 | 2022/08/16 18:45 | Swindon v Leyton Orient | D | 1-1 |
| Anglia - League 2 | 2022/08/13 14:00 | Leyton Orient v Mansfield | W | 1-0 |
| Anglia - Cupa EFL | 2022/08/09 18:45 | Forest Green v Leyton Orient | L | 2-0 |
| Anglia - League 2 | 2022/08/06 14:00 | Crawley Town v Leyton Orient | W | 0-1 |
| Anglia - League 2 | 2022/07/30 14:00 | Leyton Orient v Grimsby | W | 2-0 |
| Europa - Amicale | 2022/07/23 14:00 | Dag & Red v Leyton Orient | D | 2-2 |
| Europa - Amicale | 2022/07/19 18:00 | Leyton Orient v Portsmouth | L | 2-5 |
| Regatul Unit - Amicale | 2022/07/12 18:45 | Maidstone Utd v Leyton Orient | D | 0-0 |