[52] Andy Murray 4-6,6-7,7-6,4-6 John Isner [24] 2022-06-29 16:40
Stadium: Centre Court Round: 24 Ground: Grass
Head to Head
| ATP - Paris | 2016/11/06 14:00 | John Isner v Andy Murray | 3-6,7-6,4-6 |
| ATP - Viena | 2016/10/28 18:20 | Andy Murray v John Isner | 6-1,6-3 |
| French Open | 2016/05/29 13:20 | John Isner v Andy Murray | 6-7,4-6,3-6 |
| Challenger - Shanghai | 2015/10/15 05:30 | Andy Murray v John Isner | 6-7,6-4,6-4 |
| Cupa Davis | 2015/03/08 13:00 | Andy Murray v John Isner | 7-6,6-3,7-6 |
| ATP - Cincinnati | 2014/08/14 16:40 | Andy Murray v John Isner | 6-7,6-4,7-6 |
Home History
| Wimbledon | 2022/06/27 17:30 | Andy Murray v James Duckworth | 4-6,6-3,6-2,6-4 |
| ATP - Stuttgart | 2022/06/12 13:00 | Andy Murray v Matteo Berrettini | 4-6,7-5,3-6 |
| ATP - Stuttgart | 2022/06/11 13:30 | Andy Murray v Nick Kyrgios | 7-6,6-2 |
| ATP - Stuttgart | 2022/06/10 13:05 | Stefanos Tsitsipas v Andy Murray | 6-7,3-6 |
| ATP - Stuttgart | 2022/06/09 11:40 | Andy Murray v Alexander Bublik | 6-3,7-6 |
| ATP - Stuttgart | 2022/06/07 11:55 | Andy Murray v Christopher O'Connell | 6-4,6-3 |
| Challenger - Surbiton | 2022/06/04 14:25 | Andy Murray v Denis Kudla | 7-5,6-7,3-6 |
| Challenger - Surbiton | 2022/06/03 14:00 | Andy Murray v Brandon Nakashima | 6-4,7-6 |
Away History
| Wimbledon | 2022/06/27 12:55 | Enzo Couacaud v John Isner | 7-6,6-7,6-4,3-6,5-7 |
| French Open | 2022/05/27 13:40 | John Isner v Bernabe Zapata Miralles | 4-6,6-3,4-6,7-6,3-6 |
| French Open | 2022/05/25 09:00 | John Isner v Gregoire Barrere | 6-4,6-4,3-6,7-6 |
| French Open | 2022/05/22 11:40 | John Isner v Quentin Halys | 7-6,4-6,7-6,7-6 |
| ATP - Roma | 2022/05/11 10:50 | Rafael Nadal v John Isner | 6-3,6-1 |
| ATP - Roma | 2022/05/10 11:25 | Francisco Cerundolo v John Isner | 4-6,3-6 |
| ATP - Madrid | 2022/05/04 12:25 | Cameron Norrie v John Isner | 6-4,6-7,6-4 |
| ATP - Madrid | 2022/05/01 13:00 | Filip Krajinovic v John Isner | 6-7,4-6 |