Stadium: Robert W. Plaster Stadium Round: 1
Home Manager: Bobby Petrino Away Manager: Doug Phillips
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | W | 33-41 |
| NCAAF | 2021/04/10 19:00 | Youngstown State v Missouri St | L | 10-21 |
| NCAAF | 2017/11/18 17:00 | Youngstown State v Missouri St | W | 38-10 |
| NCAAF | 2022/11/05 19:00 | Youngstown State v Illinois State | W | 19-17 |
| NCAAF | 2022/10/29 18:00 | South Dakota v Youngstown State | W | 24-45 |
| NCAAF | 2022/10/22 20:00 | Youngstown State v Western Illinois | W | 28-27 |
| NCAAF | 2022/10/15 18:00 | Indiana State v Youngstown State | W | 42-48 |
| NCAAF | 2022/10/08 22:00 | North Dakota v Youngstown State | L | 35-30 |
| NCAAF | 2022/10/01 18:00 | Youngstown State v North Dakota State | L | 14-27 |
| NCAAF | 2022/09/17 16:00 | Youngstown State v Kentucky | L | 0-31 |
| NCAAF | 2022/09/10 18:00 | Dayton v Youngstown State | W | 16-49 |
| NCAAF | 2022/11/05 18:00 | Missouri St v South Dakota | L | 13-20 |
| NCAAF | 2022/10/29 19:00 | Western Illinois v Missouri St | W | 14-64 |
| NCAAF | 2022/10/22 21:00 | Missouri St v Northern Iowa | L | 20-41 |
| NCAAF | 2022/10/08 19:00 | SO Illinois v Missouri St | L | 38-21 |
| NCAAF | 2022/10/01 17:00 | Missouri St v North Dakota | L | 31-48 |
| NCAAF | 2022/09/24 19:00 | South Dakota State v Missouri St | L | 28-14 |
| NCAAF | 2022/09/17 23:00 | Missouri St v Arkansas | L | 27-38 |
| NCAAF | 2022/09/09 00:00 | Tennessee Martin v Missouri St | W | 30-35 |