Stadium: Mississippi Veterans Memorial Stadium Round: 1
Home Manager: Deion Sanders Away Manager: Vincent Dancy
| NCAAF | 2021/10/30 20:00 | Jackson State v Mississippi Valley State | L | 28-19 |
| NCAAF | 2021/03/14 19:00 | Mississippi Valley State v Jackson State | L | 7-43 |
| NCAAF | 2019/10/19 19:00 | Jackson State v Mississippi Valley State | L | 31-28 |
| NCAAF | 2018/10/13 19:00 | Mississippi Valley State v Jackson State | L | 7-23 |
| NCAAF | 2017/10/28 19:00 | Mississippi Valley State v Jackson State | L | 5-24 |
| NCAAF | 2022/09/17 23:00 | Mississippi Valley State v Delta State | L | 17-28 |
| NCAAF | 2022/09/10 20:00 | Mississippi Valley State v Austin Peay | L | 0-41 |
| NCAAF | 2022/09/02 00:00 | Mississippi Valley State v Tarleton State | L | 13-29 |
| NCAAF | 2021/11/27 20:00 | Mississippi Valley State v Prairie View | W | 24-19 |
| NCAAF | 2021/11/13 19:00 | Alabama State v Mississippi Valley State | W | 31-44 |
| NCAAF | 2021/11/06 18:00 | Mississippi Valley State v Alabama | L | 14-42 |
| NCAAF | 2021/10/30 20:00 | Jackson State v Mississippi Valley State | L | 28-19 |
| NCAAF | 2021/10/23 20:00 | Florida A&M v Mississippi Valley State | L | 31-28 |
| NCAAF | 2022/09/17 18:00 | Grambling State v Jackson State | W | 24-66 |
| NCAAF | 2022/09/10 23:00 | Jackson State v Tennessee State | W | 16-3 |
| NCAAF | 2022/09/04 19:00 | Florida A&M v Jackson State | W | 3-59 |
| NCAAF Bowl Games | 2021/12/18 17:00 | South Carolina State v Jackson State | L | 31-10 |
| NCAAF | 2021/12/04 21:00 | Prairie View v Jackson State | W | 10-27 |
| NCAAF | 2021/11/20 19:00 | Alcorn State v Jackson State | W | 10-24 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | W | 21-17 |
| NCAAF | 2021/11/06 18:00 | Texas Southern Tigers v Jackson State | W | 21-41 |