[5] Duke 0-23 Louisville [3] 2023-10-28 19:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Jeff Brohm Away Manager: Mike Elko
Head to Head
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | L | 62-22 |
| NCAAF | 2016/10/14 23:00 | Duke v Louisville | L | 14-24 |
| NCAAF | 2002/09/07 12:00 | Duke v Louisville | L | 3-40 |
Home History
| NCAAF | 2023/10/21 23:30 | Duke v Florida State | L | 20-38 |
| NCAAF | 2023/10/15 00:00 | NC State v Duke | W | 3-24 |
| NCAAF | 2023/09/30 23:30 | Notre Dame v Duke | L | 21-14 |
| NCAAF | 2023/09/23 19:30 | Duke v Connecticut | W | 41-7 |
| NCAAF | 2023/09/16 19:30 | Northwestern v Duke | W | 14-38 |
| NCAAF | 2023/09/09 22:00 | Lafayette v Duke | W | 7-42 |
| NCAAF | 2023/09/05 00:00 | Clemson v Duke | W | 7-28 |
| NCAAF Bowl Games | 2022/12/28 19:00 | Central Florida v Duke | W | 13-30 |
Away History
| NCAAF | 2023/10/14 22:30 | Louisville v Pittsburgh | L | 21-38 |
| NCAAF | 2023/10/07 23:30 | Notre Dame v Louisville | W | 20-33 |
| NCAAF | 2023/09/29 23:00 | Louisville v NC State | W | 13-10 |
| NCAAF | 2023/09/23 19:30 | Boston College v Louisville | W | 28-56 |
| NCAAF | 2023/09/16 16:00 | Louisville v Indiana | W | 21-14 |
| NCAAF | 2023/09/07 23:30 | Murray State v Louisville | W | 0-56 |
| NCAAF | 2023/09/01 23:30 | Louisville v Georgia Tech | W | 39-34 |
| NCAAF Bowl Games | 2022/12/17 16:00 | Louisville v Cincinnati | W | 24-7 |