Stadium: Mueller Field Round: 1
| NCAAF | 2022/11/19 18:00 | Ashland Eagles v Notre Dame Falcons | L | 20-13 |
| NCAAF | 2022/11/12 18:00 | Alderson Broaddus Battlers v Notre Dame Falcons | W | 3-27 |
| NCAAF | 2022/11/05 16:00 | Notre Dame Falcons v Unc Pembroke Braves | W | 27-0 |
| NCAAF | 2022/10/29 16:00 | Fairmont State v Notre Dame Falcons | W | 6-30 |
| NCAAF | 2022/10/22 16:00 | Notre Dame Falcons v Glenville State Pioneers | W | 38-16 |
| NCAAF | 2022/10/15 17:00 | W. Virginia Bobcats v Notre Dame Falcons | W | 9-41 |
| NCAAF | 2022/10/08 17:00 | Frostburg State v Notre Dame Falcons | L | 33-30 |
| NCAAF | 2022/10/01 16:00 | Notre Dame Falcons v University of Charleston Golden Eagles | W | 49-24 |
| NCAAF | 2022/11/12 18:00 | Ohio Dominican Panthers v Hillsdale Chargers | W | 20-10 |
| NCAAF | 2022/11/05 17:00 | Northwood Timberwolves v Ohio Dominican Panthers | W | 24-35 |
| NCAAF | 2022/10/22 17:00 | Ohio Dominican Panthers v Kentucky Wesleyan | W | 49-7 |
| NCAAF | 2022/10/15 23:00 | Ashland Eagles v Ohio Dominican Panthers | L | 14-7 |
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | W | 7-38 |
| NCAAF | 2022/10/01 17:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | W | 21-0 |
| NCAAF | 2022/09/24 17:00 | Ohio Dominican Panthers v Indianapolis Greyhounds | L | 38-44 |
| NCAAF | 2022/09/17 17:00 | Ohio Dominican Panthers v William Jewell College Cardinals | W | 31-21 |