[5] Alexander Zverev 7-6,6-3 John Isner [10] 2018-11-16 14:00
Stadium: Centre Court Round: 3 Ground: Hardcourt indoor
Head to Head
| Laver Cup | 2018/09/22 18:00 | Alexander Zverev v John Isner | 3-6,7-6,10-7 |
| ATP - Madrid | 2018/05/11 20:00 | John Isner v Alexander Zverev | 4-6,5-7 |
| ATP - Miami | 2018/04/01 17:00 | Alexander Zverev v John Isner | 7-6,4-6,4-6 |
| ATP - Roma | 2017/05/20 13:00 | Alexander Zverev v John Isner | 6-4,6-7,6-1 |
| ATP - Miami | 2017/03/27 20:40 | John Isner v Alexander Zverev | 7-6,6-7,6-7 |
| ATP - Shanghai | 2016/10/10 07:10 | Alexander Zverev v John Isner | 6-4,6-2 |