Head to Head
| ATP Atlanta | 2019/07/24 23:00 | John Isner v Reilly Opelka | 6-7,7-6,6-7 |
| ATP - New York | 2019/02/17 00:00 | John Isner v Reilly Opelka | 7-6,6-7,6-7 |
| Australian Open | 2019/01/14 02:55 | Reilly Opelka v John Isner | 7-6,7-6,6-7,7-6 |
| ATP Atlanta | 2019/07/24 23:00 | John Isner v Reilly Opelka | 6-7,7-6,6-7 |
| ATP - New York | 2019/02/17 00:00 | John Isner v Reilly Opelka | 7-6,6-7,6-7 |
| Australian Open | 2019/01/14 02:55 | Reilly Opelka v John Isner | 7-6,7-6,6-7,7-6 |