The LPU Pirates are the athletic teams that represent the Lyceum of the Philippines University and plays in the National Collegiate Athletic Association (Philippines), the oldest athletic association in the Philippines. Lyceum has fifteen collegiate men's varsity teams that participate in fifteen sporting events of the National Collegiate Athletic Association (Philippines), its mother league. They are popularly known as the "Pirata ng Intramuros". The women's varsity team is called the Lady Pirates, which plays in the Premier Volleyball League (PVL) while the high school varsity basketball team is from the Cavite Campus' International High School which is called the Junior Pirates. The university takes part in various sports leagues and tournaments such as the Filoil Flying V Preseason Cup, Fr. Martin's Cup, Philippine Collegiate Champions League, Milcu Sports Basketball Presents Got Skills Premier League, PBA Developmental League and Premier Volleyball League (PVL). Lyceum of the Philippines University is the youngest member of the National Collegiate Athletic Association (Philippines).
Lyceum is one of the six candidates sought by the NCAA Management Committee (MANCOM) as a replacement for Philippine Christian University. In 2009, however, Lyceum failed to complete the necessary requirements to join the league, including the existence of a high school program. Two years later, Lyceum was finally accepted as a guest-team member, completed the necessary requirements including having a high school department located in its Cavite campus.
In 2015, Lyceum was finally admitted to the NCAA as a regular member.
Lyceum together with FEATI University, Manila Doctors College, Southville International School and Colleges, Manila Adventist Medical Center and Colleges and La Consolacion College Manila formed the Inter-Scholastic Athletic Association (ISAA) back in 2009. They eventually became the basketball champions both men's and women's up until the 2010 season. After the 2010 season they left the league to pursue their dreams in the NCAA.
In the WNCAA they are back-to-back champions in 2010 and 2011 r fhaitusespectively. Right now they are on hiatus.