| NCAAB | 12/05 00:00 | - | East Carolina v USC Upstate | L | 82-71 | |
| NCAAB | 12/03 00:00 | - | Clemson v USC Upstate | L | 76-56 | |
| NCAAB | 12/01 00:00 | - | USC Upstate v Toccoa Falls | W | 101-54 | |
| NCAAB | 11/28 19:00 | - | USC Upstate v The Citadel | L | 81-88 | |
| NCAAB | 11/27 22:00 | - | USC Upstate v Georgia Southern | L | 80-84 | |
| NCAAB | 11/25 00:00 | - | USC Upstate v Winthrop | L | 78-79 | |
| NCAAB | 11/21 19:00 | - | USC Upstate v Bob Jones University | L | 79-83 | |
| NCAAB | 11/20 00:30 | - | USC Upstate v Navy | L | 55-67 | |
| NCAAB | 11/17 00:00 | - | Presbyterian v USC Upstate | L | 74-73 | |
| NCAAB | 11/14 02:30 | - | Texas A&M v USC Upstate | L | 104-64 | |
| CIT | 03/21 22:00 | 124 | USC Upstate v Tennessee Martin | L | 49-60 | |
| CIT | 03/17 23:00 | 122 | USC Upstate v James Madison | W | 73-72 | |
| NCAAB | 03/08 18:30 | 142 | North Florida v USC Upstate | L | 63-57 | |
| NCAAB | 03/06 00:00 | 2 |
Florida Gulf Coast
v
USC Upstate
|
W | 62-63 | |
| NCAAB | 03/04 00:00 | 3 | USC Upstate v Kennesaw State | W | 90-54 | |
| NCAAB | 03/01 00:00 | - |
Northern Kentucky
v
USC Upstate
|
L | 84-65 | |
| NCAAB | 02/25 23:00 | - |
USC Upstate
v
Lipscomb
|
W | 70-47 | |
| NCAAB | 02/22 00:00 | - |
Florida Gulf Coast
v
USC Upstate
|
L | 86-72 | |
| NCAAB | 02/20 00:00 | - | Stetson v USC Upstate | W | 54-73 | |
| NCAAB | 02/14 19:00 | - | USC Upstate v Jacksonville | L | 70-89 | |
| NCAAB | 02/13 00:00 | - | USC Upstate v North Florida | W | 80-63 | |
| NCAAB | 02/07 20:00 | - | Kennesaw State v USC Upstate | W | 46-74 | |
| NCAAB | 02/03 12:00 | 1 | USC Upstate v St. Andrew's | W | 79-39 | |
| NCAAB | 02/01 00:00 | - | North Florida v USC Upstate | W | 74-79 | |
| NCAAB | 01/30 00:00 | - | Jacksonville v USC Upstate | W | 65-78 | |
| NCAAB | 01/24 19:00 | - | USC Upstate v Stetson | W | 91-67 | |
| NCAAB | 01/23 00:00 | - |
USC Upstate
v
Florida Gulf Coast
|
L | 68-71 | |
| NCAAB | 01/17 19:00 | - |
USC Upstate
v
Northern Kentucky
|
L | 65-66 | |
| NCAAB | 01/14 00:30 | - |
Lipscomb
v
USC Upstate
|
L | 60-58 | |
| NCAAB | 01/10 19:00 | - | USC Upstate v Kennesaw State | W | 68-65 |
Echipa de baschet masculin a Universității Carolinei de Sud Upstate, cunoscută și sub numele de USC Upstate Spartans, reprezintă Universitatea din Carolina de Sud Upstate din Divizia I a NCAA. Spartans joacă meciurile de acasă la G. B. Hodge Center din Spartanburg, Carolina de Sud, iar antrenorul principal este Dave Dickerson. USC Upstate este membru al Conferinței Big South.