[5] BUF Sabres 4-7 FLA Panthers [1] 2021-12-03 00:00
Stadium: Amerant Bank Arena
Home Manager: Andrew Brunette Away Manager: Don Granato
Head to Head
| NHL | 2020/01/04 18:00 | FLA Panthers v BUF Sabres | W | 2-3 |
| NHL | 2019/11/24 22:00 | BUF Sabres v FLA Panthers | W | 5-2 |
| NHL | 2019/10/11 23:00 | FLA Panthers v BUF Sabres | W | 2-3 |
| NHL | 2019/02/20 00:00 | BUF Sabres v FLA Panthers | L | 2-4 |
| NHL | 2019/01/04 00:00 | FLA Panthers v BUF Sabres | W | 3-4 |
| NHL | 2018/12/19 00:00 | FLA Panthers v BUF Sabres | L | 5-2 |
| NHL | 2018/12/01 00:00 | BUF Sabres v FLA Panthers | L | 2-3 |
| NHL | 2018/04/07 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
Home History
| NHL | 2021/11/30 00:00 | SEA Kraken v BUF Sabres | L | 7-4 |
| NHL | 2021/11/28 00:00 | BUF Sabres v DET Red Wings | L | 2-3 |
| NHL | 2021/11/27 00:00 | MON Canadiens v BUF Sabres | W | 1-4 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/11/23 00:00 | CLB Blue Jackets v BUF Sabres | L | 7-4 |
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2021/11/19 00:00 | CAL Flames v BUF Sabres | L | 5-0 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | W | 2-1 |
Away History
| NHL | 2021/12/01 00:00 | WAS Capitals v FLA Panthers | W | 4-5 |
| NHL | 2021/11/27 23:00 | SEA Kraken v FLA Panthers | L | 4-1 |
| NHL | 2021/11/26 22:00 | FLA Panthers v WAS Capitals | L | 3-4 |
| NHL | 2021/11/25 00:00 | PHI Flyers v FLA Panthers | W | 1-2 |
| NHL | 2021/11/20 23:00 | MIN Wild v FLA Panthers | W | 4-5 |
| NHL | 2021/11/19 00:00 | NJ Devils v FLA Panthers | W | 1-4 |
| NHL | 2021/11/17 00:00 | NY Islanders v FLA Panthers | W | 1-6 |
| NHL | 2021/11/14 00:00 | FLA Panthers v TB Lightning | L | 2-3 |