[21] FLA Panthers 4-3 BUF Sabres [18] 2022-10-15 17:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Paul Maurice
Head to Head
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | W | 3-4 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | W | 5-3 |
| NHL | 2022/03/08 00:00 | FLA Panthers v BUF Sabres | W | 6-1 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | W | 4-7 |
| NHL | 2020/01/04 18:00 | FLA Panthers v BUF Sabres | L | 2-3 |
| NHL | 2019/11/24 22:00 | BUF Sabres v FLA Panthers | L | 5-2 |
| NHL | 2019/10/11 23:00 | FLA Panthers v BUF Sabres | L | 2-3 |
| NHL | 2019/02/20 00:00 | BUF Sabres v FLA Panthers | W | 2-4 |
Home History
| NHL | 2022/10/13 23:30 | FLA Panthers v NY Islanders | W | 3-1 |
| NHL - Presezon | 2022/10/08 20:00 | FLA Panthers v TB Lightning | L | 2-5 |
| NHL - Presezon | 2022/10/06 23:00 | TB Lightning v FLA Panthers | W | 2-3 |
| NHL - Presezon | 2022/10/01 17:00 | FLA Panthers v CAR Hurricanes | L | 3-4 |
| NHL - Presezon | 2022/09/29 23:00 | CAR Hurricanes v FLA Panthers | L | 5-2 |
| NHL - Presezon | 2022/09/27 00:00 | FLA Panthers v NAS Predators | L | 0-4 |
| NHL - Presezon | 2022/09/26 20:00 | FLA Panthers v NAS Predators | W | 4-3 |
| NHL | 2022/05/23 23:00 | FLA Panthers v TB Lightning | L | 0-2 |
Away History
| NHL | 2022/10/13 23:00 | OTT Senators v BUF Sabres | W | 1-4 |
| NHL - Presezon | 2022/10/07 23:00 | BUF Sabres v PIT Penguins | L | 1-7 |
| NHL - Presezon | 2022/10/04 23:00 | CAR Hurricanes v BUF Sabres | W | 2-4 |
| NHL - Presezon | 2022/10/01 17:00 | PIT Penguins v BUF Sabres | W | 1-3 |
| NHL - Presezon | 2022/09/28 23:00 | BUF Sabres v CLB Blue Jackets | L | 1-4 |
| NHL - Presezon | 2022/09/27 23:00 | PHI Flyers v BUF Sabres | W | 1-2 |
| NHL - Presezon | 2022/09/25 18:00 | BUF Sabres v WAS Capitals | W | 4-3 |
| NHL | 2022/04/29 23:00 | CHI Blackhawks v BUF Sabres | W | 2-3 |